Install an all in one packages (visual c++, etc) (or this for .net too) into your wine prefix and run the repacks (like fitgirl or dodi) like in windows.

Put dxvk and vkd3d-proton on your wineprefix (automated like with cachyos or manually downloaded) and maybe create a lutris application to just select the exe to install the game.

Edit: Also jc141

Edit 2: Added one link for the .net ones, run the wine cmd for these packages and they autoinstall all the gaming dependencies, so you can install almost any games. Also, you can install dependencies (like those needed by some games like skyrim) using winetricks.

Edit 3: Updated the link